Hypoxia-inducible Factor-1α Protein Negatively Regulates Load-induced Bone Formation*
نویسندگان
چکیده
منابع مشابه
Hypoxia-inducible factor-1α protein negatively regulates load-induced bone formation.
Mechanical loads induce profound anabolic effects in the skeleton, but the molecular mechanisms that transduce such signals are still poorly understood. In this study, we demonstrate that the hypoxia-inducible factor-1α (Hif-1α) is acutely up-regulated in response to exogenous mechanical stimuli secondary to prostanoid signaling and Akt/mTOR (mammalian target of rapamycin) activation. In this c...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2011
ISSN: 0021-9258
DOI: 10.1074/jbc.m111.276683